Berlusconi said China has made important contributions to world economic recovery by maintaining steadfast and rapid economic growth. China had the best market for investment with great potential, he said.
Agreeing on Wen's proposals for cooperation, Berlusconi pledged that Italy would work closely with China to bring more benefits to the people of both countries.
After the meeting, the two leaders also attended the signing ceremony of agreements between the two governments on economy, science and technology, culture and justice.
They also met representatives of industrial communities of the two countries.
Wen arrived in Italy on Wednesday, the third leg of his four-nation tour, which has already taken him to Greece and Belgium. He held an unscheduled meeting with German Chancellor Angela Merkel in Germany on Tuesday and will also visit Turkey before returning to China.