In their previous three meetings, Sharapova walked off with three victories. But this time the table was turned around.
The big-hitting 15th-seeded German broke Sharapova's serve three times in the first set and once early in the second, not allowing the Russian any chance to come back. The score, 6-4, 6-3.
"It's just unbelievable, you know. For the third time, I've beaten the French Open Champion here. I'm just so happy. I've lost three previous meeting against her. Now I just played well. I fought to the last point. The last game was tough but I fought it out I'm just happy."
Lisicki will face compatriot 8th-seeded Angelique Kerber, who smashed Belgian veteran Kim Clijsters 6-1, 6-1 to reach the quarter finals.
Defending champion Czech Petra Kvitova came from one set down to oust Francesca Schiavone of Italy 4-6, 7-5, 6-1 to reach the quarter finals. 2nd-seeded Victoria Azarenka of Belarus powered past Ana Ivanovic of Serbia 6-1, 6-0. Four-time champion Serena Williams beat Yaroslava Shvedova of Kazakhstan 6-1, 2-6, 7-5. 3rd-seeded Agnieszka Radwanska of Poland saw off Camila Giorgi of Italy 6-2, 6-3. 37th-ranked Austrian Tamira Paszek, the champion at Eastbourne in the week leading up to Wimbledon, beat Roberta Vinci of Itlay 6-2, 6-2. And 17th-seeded Maria Kirilentko of Russia defeated 30th-seeded Peng Shuai of China 6-1, 7-6, 6-3.
In men's singles, defending champion Novak Djokovic of Serbia eased past compatriot Viktor Troicki 6-3, 6-1, 6-3 to reach the last eight. 3rd-seeded Roger Federer of Switzerland defeated Xavier Malisse of Belgium 7-6, 6-1, 4-6, 6-3. And Russia's Mikhail Youzhny outperformed Uzbekistan's Denis Istomin 6-3, 5-7, 6-4, 6-7, 7-5 to reach the quarterfinals at Wimbledon for the first time.
Five matches including the one between Croatia's Marin Cilici and Britain's Andy Murray were suspended or canceled because of rain.
For CRI, I'm Tu Yun reporting from Wimbledon.
